Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?
نویسندگان
چکیده
منابع مشابه
Weight gain with antipsychotics: What role does leptin play?
Clinical studies indicate that clozapine and olanzapine carry a high risk of treatment-related metabolic dysfunction—including weight gain, hyperlipidemia, and glucose intolerance—but certain patients with high metabolic liabilities who take atypical antipsychotics do not necessarily develop these adverse effects. Though the underlying mechanism for atypical antipsychotic-related weight gain is...
متن کاملThe Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of researc...
متن کاملLeptin -2548g/a gene polymorphism in association with antipsychotic-induced weight gain: a meta-analysis study.
BACKGROUND The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychotic-induced weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the relationship between the leptin -2548G/A gene polymorphism and AIWG. METHODS Electronic databases were searched for eligible articles in English and ...
متن کاملDoes leptin play a role in obesity-asthma relationship?
The increase of asthma has paralleled the rising obesity during the past decades. Obesity is characterized by the increase of leptin in the circulation. Leptin is an obesity gene product, and it can stimulate the production of pro-inflammatory mediators, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and interferon (IFN)-gamma. There is a link between leptin and asthma, especiall...
متن کاملAre leptin and cytokines involved in body weight gain during treatment with antipsychotic drugs?
OBJECTIVE To critically review published literature on the causal association between leptin, cytokines, and excessive body weight gain (BWG) induced by antipsychotic drugs (APs). METHODS We completed a Medline search using the words leptin, cytokines, antipsychotic drugs, neuroleptics, psychotropic drugs, weight gain, and obesity. We also included our empirical research on this topic in the ...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2020
ISSN: 1476-511X
DOI: 10.1186/s12944-020-01203-z